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Medical Biochemistry-Bile salts - Coggle Diagram
Medical Biochemistry-Bile salts
Liver Functions
Protein & amino-acid metabolism
: synthesis of plasma proteins , AA deamination & urea synthesis
Lipid Metabolism
: Synthesis of Triglycerides & Fat metabolism
Carbs Metabolism
:Maintains glucose levels
Detoxification & Excretion
>metabolism & excretion of foreign products(xenobotics),steroid hormones activation, production & excretion of bilirubin
Bile Acid metabolism
-Cholesterol synthesis, circulation of bile acids , conjugation with glycin to form bile salts
Bile
Composition
:H20,
Bile salts
(conjugated with
taurine or glycine
, which are hydrophilic, to make a better surfactant),
bilurubin
, inorganic ons, cholesterol,phospholipids
Bile Synthesis
Difference btwn Chenodeoxycholic & cholic acid: Hydroxyl group added to one of the rings
Liver makes Cholesterol more
hydrophilic:
Add carboxyl group & hydroxyl group
Synthesized
from Cholesterol
>converted to either
chenodeoxycholic
acid &
Cholic acid
Bile salts: Amphipathic
Important for conversion of cholesterol to bile acids>only convert molecule with one hydroxyl group to multiple hydroxyl groups
Cholic acids & chenodeoxycholic acids has hydroxylic groups on one side of molecule=
hydrophilic face
, Hydrogens & carbons on the other side=
Hydrophobic
Function of bile salts
Form Micelles:
Bile salts coats edge of micelle(have
hydrophilic
(contacts aqueous solution) &
hydrophobic
(interacts with micelle & fatty acids chains)
Lipids & cholesterol assemble into micelles(in intestines)
Absorbs fats & fat soluble vitamins
Provides Large surface area for pancreatic lipase action