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Malignant Hyperthermia - Coggle Diagram

- - - - Mutated ryanodine receptors in the skeletal muscle.
        
        This interferes with the regulation of calcium in the skeletal muscle.
        
        This improper regulation leads to a build-up of calcium in the skeletal muscle.
        
        The build-up results in a massive hypermetabolism.
        
        Leading to excessive heat, depletion of ATP, and production of CO2.
        
        This leads to extensive muscle cell damage if unrecognized.
        
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