Please enable JavaScript.

Coggle requires JavaScript to display documents.

Antibiotic resistance in bacteria (Barta et al. 2021), Works cited Aditi…

- - - - β-lactams (carbenicillin, doripenem and cefsulodin)
    - - non β-lactams
    - - Based on growth and genome sequence, the β-lactam arm had more effective antibacterial activity than the arm of antibiotics with differing mechanisms of action. Surprising, because antibiotics within the same class should be selective enough to accelerate the selection for and evolution of bacteria with antibiotic resistant properties.
        
        Further, quickly switching between different β-lactams resulted in higher antibiotic activity than exposing the bacteria to a single agent, suggesting that this inhibited the further evolution of the bacteria's antibiotic resistance.
      - Discussion
        
        Colatteral sensitivity
        
        Development of antibiotic resistance to doripenem was lower when treated with other drugs in the β-lactam sequence. Even when bacteria develop resistance to drugs with the same mechanism of action given later in the sequence, they remain susceptible to drugs given earlier in the sequence such as doripenem.
        
        This colatteral sensitivity is an important component in treating these infections of antibiotic resistant bacteria. Resistance to one drug within a class does not mean the bacteria would be resistant to other drugs within the same class.