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cell mediated immunity - Coggle Diagram

- - - - PD-L
    - - CD40
    - - : B7
    - - ICOS-L
    - - paracrine
      - endocrine
      - autocrine
      - 補充：IL-2讓T cell affinity up
  - - - 訊息來，IkB磷酸化，被加ubiquitin(泛素)
    - - 膜上PIP2藉由 PI3 kinase 變成PIP3
        mTOR促進蛋白質合成
    - - active enzyme：calcineurin (把NFAT去磷酸)
      - 膜上PIP2變成IP3，Ca2+大量跑出體外
  - - - Th2
        
        IL-4, IL-5, IL-13
        
        eosinophil
        
        parasite; allergy
        
        M2
      - Th17
        
        neutrophil
        
        extracellular pathogen; acute inflammation
        
        IL-17, IL-19
        
        response
        
        antimicrobial peptide：defensin
        
        barrier integrity
        
        neutrophil response
      - Th1
        
        macrophage
        
        intracellular pathogen; chronic inflammation
        
        INFr
        
        M1
    - - CTL
        
        granule exocytosis
        
        peforin (entry for granzyme)
        
        granzyme B (activate apoptosis)
        
        FasL
        
        FADD：DD(death domain)+DED(death effector domain)
        
        DED會接到pro-caspase8 and initiate apoptosis
        
        Fas(CD95) on target cells
  - - - chemokine
      - selectin
      - integrin
    - - CD62(L-selectin)
        
        L-selectin ligand
      - LFA-1(stick together)(integrin)
        
        ICAM-1
      - CCR7(chemokine)
        
        CCL19, CCL21