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CHEM PATH:DIARRHEA (2) - Coggle Diagram
CHEM PATH:DIARRHEA (2)
Acute Diarrhea
Lots of electrolytes(major:Na , either K+/HCO3) lost in stool=
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Too quick for H2O to be absorbed, No time for Na/K/H exchange
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Chronic
Renin angiotensin activated>DCT absorbs Na in exchange of K/H>low K+>instead of excreting K+ , excrete more H+ ions>leads to metabolic alkalosis
This is 2ndary K+ depletion: less K available for exchange for Na in distal renal tubule due to chronic loss of K in stool
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lose Na,water, lose more K(can become whole body potassium depleted)>
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Hyperemesis
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urine acidic even though there is metabolic alkalosis,more HC03 absorbed,hyperaldosteroism
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Steatorrhoea
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Cause:Enterogenous- luminal (giardia), mucosal (coeliac disease, crohns et), lymphatic (TB,
lymphoma),Pancreatic – lack of lipase, Biliary – lack of bile salts
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Lab tests: Stool histology(stain with Oil red O, Steatocrit, Radioisotope(13CO2 in breath)
Clinic manifestation:weight loss,def. of Vit A.D.K