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Premature Ageing Syndrome - Coggle Diagram
Premature Ageing Syndrome
Defination
Premature ageing syndromes, also known as progeria, include two very rare inherited conditions, Hutchinson-Gilford syndrome and Werner syndrome.
Patient born with this syndrome typically live an age of mid teens tot early twenties.
Aetiology
Photo Defence
Skin damage and skin cancer and Exposure ultraviolet light from the sun
Mutation that weakens the structure of the cells nucleus
Clinical Manifestation
Fully body alopecia, which is hair loss
Narrowed face with small lower jaw and beaked nose
Limited growth with below-average height and weight
Head became large including the face
Pathophysiology
Heart problems and stroke are the major problem of thus syndrome and the average life expectancy for a patient with ageing syndrome is about 13 - 14 years
Patient with progeria generally appear normal at birth.
Progeria is accelarated aging syndrome caused by mutation
Some people may be die young and there is no cure for aging
Laminopathies are the diseases caused by mutation in the component of the nuclear lamina
Treatment
Pravastin
Morpholinos and Inhibitors
Growth Hormone treatment
References
Progeria. National Institutes of Health.
https://report.nih.gov/nihfactsheets/viewfactsheet.aspx?csid=59
. Accessed Feb. 1, 2017.
National Library of Medicine. Hutchinson-Gilford progeria syndrome. Genetics Home Reference.
https://ghr.nlm.nih.gov/condition/hutchinson-gilford-progeria-syndrome
. Accessed Feb. 1, 2017.