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METABOLIC SYNDROME, short chain fatty acid - Coggle Diagram

- - - - Dangers of visceral fat
        
        Insulin resistance
        
        T2D
        
        High triglycerides
        
        Insulin resistance in muscles
        
        Inflammation
        
        IR
        
        Altered cytokine levels
        
        Increase IR and lipolysis
        
        further FFA secretion
        
        CVD
        
        Excess secretion of VLDL and excess hepatic gluconeogenesis
        
        Decrease HDL, Increase small dense LDL
        
        Atherosclerotic dyslipidemia
- - - - most important factor
    - - Men are at greater risk
    - - High HDL decreases risk
      - high LDL, VLDL increases risk
    - - increase in weight results in high BP, insulin resistance, increase in fibrinogen levels an cholesterol levels
  - - - first dreg relative increases risk by 4x
    - - more than two units per day of alcohol increases risk of CHD
      - very small intake of alcohol increases HDL, decreasing risk of CHD
- - - - Leptin
        
        GLP-1 agonist, Liraglutide