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PHARMACOLOGY-ART(pt.1) - Coggle Diagram
PHARMACOLOGY-ART(pt.1)
Indications of ART
Treatment-viral replication suppression>immune recovery, health improvement,↓ morbidity & mortality
Prevention-sexual expo(PrEP,PEP,treat HIV+ partner), ,occupational exposure & vertical transmission
ART
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Disadvantages of early ART: Resistance , long term side effects,↑costs
Newer ART=Safer, less resistance, prolonged survival & effective,↓ transmission
Integrase inhibitors-bind to catalytic domain of integrase enzyme, DTG
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Fusion Inhibitors-prevent the final stage of HIV fusion, enfurvitide
CCR5 Antagonists-Entry inhibitors, ineffective if CXCR4 is used , maraviroc
ART INTERACTIONS
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substrates-NNRTIs, PIs, DTG(broken to metabolites) , Inducers-rifampicin(speed functioning of the enzyme), inhibitors-PIs-Ritonavir(slows down enzyme function),
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