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PHARMACOLOGY-ART Pt.2 - Coggle Diagram
PHARMACOLOGY-ART Pt.2
GUIDELINES
Delay: Cryptococcal & TB MENINGITIS(↑ death)>TB meningitis-after 8 wks of TB treatment, Crypto:4-6 wks after anti-fungal therapy
Delay: TB @ non-neurological site: CD<50=2 wks after TB treatment , CD4>50=8 wks after TB
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Psychosocial issues: Px Education, treat depression & substances abuse, Px support
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ART
Accumulation of resistance mutations>affect the entire class of ARVs>Resistance achieved , the transmitted>Virus less fit
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Resistance barriers
Intermediate, Thymide analogues;zidovudine(need several mutations=complete resistance),unboosted PIs
High:Boosted PIs, dolutegravir
Low-rapid, NNRTIs-efavirenz/NRTIs-lamivudine
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Benefits & Risks of DTG,s27