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IMMUNODEFICIENCY DISEASES-AIDS - Coggle Diagram
IMMUNODEFICIENCY DISEASES-AIDS
1º(Congenital)
Disorders
Common variable immunodef.
>>defects in Ab production(unknown cause)
Selective/Isolation of IgA production
>>failure of IgA production(unknown cause)
XLA:
Failure of B-Cell maturation>no antibodies>BTK mutations
X-SCID
>Failure of T & B cell maturation
Autosomal SICD
>failure of T-Cell Dev.>2º defect in antibody responses
Causes>>mutations in genes involving lymphocyte maturation/ innate immunity
2º(acquired)
Common Cause >>
therapy induced supression
of bone marrow/lymphocyte function
Infections
>AIDS,Measles
Malignancy
>Hodkin's disease
Iatrogenic
(Radiation,chemotherapy,steroids,cyclosporin)
Other
(malnutrition,AI disease,CRF, Sarcoidosis)
AIDS
Characteristics:
Opportunistic infections & Malignancies
Opportunistic infections
Severe & lethal disease
Rare organisms
Results from HIV
Bacterial infections
BCG Adenititis>>
TB
Opportunistic infections
Fungal infections
Candidiasis
>infection of oral cavity, eosophagus, skin (e.g thrush)
Cryptococcus
>>major=meningitis
Pneumocystis jiroveci
:Pneumonia in AIDS
Histoplasmosis
>pneumonia, disseminated disease
Microsporidium
>>chronic diarrhea
Protozoal infections
Toxoplasmosis
=pneumonia, encephalitis, CNS masses
cryptosporidium, Isospora belli
=persistent diarrhoea
Viral infections
HPV(JC virus)
Herpes Complex
Cytomeagalovirus