Please enable JavaScript.
Coggle requires JavaScript to display documents.
MED MICRO-Serology Pt.2 - Coggle Diagram
MED MICRO-Serology Pt.2
-
-
Non-Treponemal Serology
Non specific-detects antibodies to non-treponemal antigens released from infected and damaged host cells.
,examples: RPR & VDRL
-
false-positive reactions occurs in >pregnancy, febrile, hepatitis C
-
RPR
-
No reaction(negative) , reaction=positive
-
Serial dilution>only done for +ve RPR on diluted sample
Prozone effect>High antibody levels inhibit agglutination reaction
-
Treatment
Primary/secondary/early latent syphilis benzathine penicillin 2.4 MU IM as a single dose (This is the dose for adults
Latent syphilis/syphilis of unknown duration/non neurological tertiary syphilis :benzathine penicillin 2.4 MU IM at weekly intervals x 3 doses ( adult dose)
-
Neurosyphilis Penicillin G 2.4 MU per day administered 4-6 hourly IV for 10-14 days ( adult dose)
Congenital syphilis> Penicillin G IV for 10 – 14 days (paediatric dosing and frequency will depend on the age and weight of the child)
-