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Hemodynamics, Plasmin, vWF factor, Factor V-II, Factor XII, Thrombomodulin…

- - - - Dyspnea/ Hypoxemia
      - Neurologic symptoms
      - Petechial rash on chest
  - - - Dyspnea
      - Cyanosis
      - Hypotensive shock
  - - - Caisson disease
- - - - Pleural effusion
      - Pericardial effusion
  - - - Impaired venous return
      - CHF
        
        Hypoperfusion
      - DVT
      - Hyperaldosteronism
    - - Cirrhosis
      - Nephrotic syndrome
      - Protein malnutrition
    - - Filariasis
        
        Wuchenneria Bancrofit
        
        Elephantiasis
      - Breast cancer
        
        Peau d'orange
      - Lymphedema
        
        Chemotherapy
    - - PSGN
      - Renal failure
  - - - Nephritic syndrome
    - - LVF
      - ARDS
      - Acute renal failure
    - - Lethal
      - flattening of gyri
- - - - NO and PGI2 from endothelium
  - - - Platelet adhesion
        
        Spiky shape change
        
        Secretory granules
        
        Alpha Granules
        
        P-selectin
        
        Traps leukocytes and others into the blood clot
        
        Fibrinogen
        
        Factor V
        
        activated by factor II
        
        Fibrinonectin
        
        PDGF
        
        Sigma granules
        
        ADP
        
        -
        
        1 more item...
        
        ADPase from endothelium
        
        Ca2+
        
        to activate coag. cascade
        
        Epinephrine
        
        alteration in GpIIb/IIIa
        
        Phospholipid Surface
        
        Required for coagulation cascade
        
        Limiting factor for coagulation
        
        Calcium attachment
        
        to gamma-carboxy regions
        
        created by Vit. K
        
        1 more item...
        
        Disorders
        
        Glanzzman Thrombasthenia
        
        ITP
      - Platelet activation
  - - - Thrombin
        
        Fibrinogen
        
        Fibrin
        
        Meshwork
        
        Activation of platelets plus
        
        D-dimers
        
        binding
  - - - Flow of blood limiting factor for coagulation
    - - Plasminogen
        
        PAI
- - - - Expose vWF to SEC
      - Endothelial activation
        
        Decreased thrombomodulin
        
        Increased PAI and decreased TPA
    - - Endothelial activation
      - Longer exposure
      - Slows washout of clotting factors
      - Types
        
        Stasis
        
        Cardiac mural thrombi
        
        MI
        
        Ventricular remodelling
        
        Atrial thrombi
        
        A fib
        
        LA dilatation
        
        MV stenosis
        
        Hyperviscosity syndrome
        
        PCV
        
        Sickle cell
        
        Turbulence
    - - Primary
        
        Leiden mutation
        
        recurrent DVT
        
        Factor V resistant to Protein C
        
        Arg506Gln
        
        Prothrombin mutation
        
        Increased Homocysteine levels
        
        Decreased cystathionine synthase
        
        AT-III deficiency
        
        High dose heparin followed by warfarin
        
        Protein C/S deficiencies
        
        AD
      - Secondary
        
        Cardiac failure
        
        OC
        
        Pregnancy
        
        Cancers
        
        Procoag tumor products
        
        Mucin from adenocarcinoma
        
        Age, Smoking, Obesity
        
        HIT
        
        IgG antibodies against Heparin-Platelet factor IV complexes
        
        Antiphospholipid syndrome
        
        Symptoms
        
        Syphillis Therapy
        
        Types
        
        Primary
        
        Secondary
  - - - Atherosclerosis
    - - Red thrombi
      - Saphenous veins
      - DVT
      - More dangeous above knee jt.
    - - Lines of Zahn
      - Attachment
    - - Infective endocarditis
      - Nonbacterial thrombotic endocarditis
        
        sterile
      - Libman Sacks
  - - - Mycotic aneurysm
  - - - Trousseau Syndrome
- - - - Hemothorax
    - - 1-2mm
      - Decreased Platelets
      - Vit. C deficiency
    - - 3-5mm
      - Trauma
      - Vasculitis
      - Same as petechiae
    - - 1-2cm
      - bruises
      - vital reaction
- - - - Hemorrhagic
      - Simple hypovolemic
    - - Septic
      - Anaphylactic
      - Neurogenic
- - - - Heart failure cells
    - - Nutmeg liver
- - - - Factor V and Factor VIII