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Pellets : - Coggle Diagram
Pellets :
PELLETIZATION
Pelletization is an agglomeration process, that converts fine powder blend of drug(s) and Excipients into small, free flowing, spherical units, referred to as pellets.
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Definition
Pellets are small spherical free flowing units with improved flow properties and flexibility in formulation development and manufacture.Their size and shape allow their administration as injections and also for oral drug delivery.
Pellets range in size, typically, between 0.5 – 1.5 mm, though other sizes could be prepared.
Advantages
They can be divided in to desired dosage strength without process or formulation changes.
They can also be blended to deliver incompatible bioactive agents.
They can also be used to provide different release profile at the same or different sites in the gastrointestinal tract.
Disadvantages
Dosing by volume rather than number and splitting into single dose units as required.
Involves capsule filling which can increase the costs or tabletting which destroy film coatings on the pellets.
The size of pellets varies from formulation to formulation but usually lies between 1 to 2mm.
Why pellets
Excellent Stability.
𝗈 Dust free Round pellets.
𝗈 Good flow behavior.
𝗈 Easy to dose.
𝗈 Compact structure.
𝗈 Very Low hygroscopicity.
𝗈 High bulk density.
𝗈 Dense, uniform surfa