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Graves Disease, PPD: - Coggle Diagram

- - - - exopthalmos
        
        damage to the cornea from eye dryness
      - damage to muscle controlling upper eyelid
        
        lid lag
      - possible inflammatory damage to optic nerve
        
        optic nerve neuralgia
  - - - accumulation of mucopolysaccharides mixing with water in reticular layer of dermis
        
        non pitting oedema
- - - - some Graves disease patients have episodes of hypothyroidism
- - - - HYPERTHYROIDISM
- - - - increased BMR = increased catabolism = weightloss despite increased appetite
    - - proliferation + hypertrophy of follicular cells = goiter
    - - inflammation + proliferation of connective tissue in periorbital space = proliferation = exopthalmos/proptosis
    - - proximal muscle weakness = catabolic state = increased proteolysis = muscle wasting
    - - increased expression of beta-adrenergic receptors = tremor + increased HR + increased cardiac output + permissive for catecholamines = increased sympathetic activation
    - - increased bowel transit time
    - - Vitals: higher body temp (thermogenesis); high normal resp rate (increased cellular metabolism = increased CO2 production = increased RR); high HR (see above)
    - - dec. amount of protein phospholamban
        
        inc. cardiac contractility
        
        high metabolic rate
        
        metabolic end products causing vasodilation of peripheral blood vessels
        
        dec. peripheral vascular resistance