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PELLETS, Formulation
requirement, Definition, size: between 0.5 – 1.5 mm…
PELLETS
Pelletization is
agglomeration an process, that converts fine powder blend of drug(s) and Excipients into small, free flowing, spherical units, referred to as pellet
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Small free flowing spherical units ranging in size, prepared by agglomeration
of fine powders are called pellets.
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Mechanism
The mechanism of agglomerate formation and growth to a pellet is believed to occur in the following stages.
Nucleation
Coalescence and layering
Ball and growth phase
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size: between 0.5 – 1.5 mm
Advantages of pellet
-Controlled release application of pellets due to the ideal low surface area to volume ratio.
-Pellet dosage forms are less susceptible to dose dumping Phenomena.
-Extends day time and night time activity of the drugs.
- Reduced dosage frequency of dosage forms.
-Increased patient compliance.
Disadvantage of pellet
-Its difficult to compress pellets into tablets as they are too rigid
-Pelletization demands highly sophisticated and expensive equipments.
-The size of pellets varies from formulation to formulation but usually lies between 1 to 2mm.