Please enable JavaScript.

Coggle requires JavaScript to display documents.

4 type quá mẫn :1234: Hypersensitivity, Type 3, type 2 :fire: cytotoxic…

- - - - histamine :arrow_heading_up:increases vascular permeability :burrito: :point_right::skin-tone-5: help :speech_balloon: immune complexes attach :swimmer::skin-tone-3: to the basement membrane of the blood vessels :burrito: :point_right::skin-tone-6: Complement clevaved products C3a :pregnant_woman::skin-tone-2::heavy_plus_sign:C5a :pregnant_woman::skin-tone-6: are yếu tố hóa ứng động Chemotactic factors :point_right::skin-tone-5: attract :dancer::skin-tone-2::bikini: Neutrophils
        
        the Neutrophile try to phagocytize immune complexes nhưng không được :forbidden: :point_right::skin-tone-5: the Neutrophiles release Lytics enzym & free radicals :point_right::skin-tone-4: causing tissue necrosis & inflammation :point_right::skin-tone-5: the Neutrophil produce mediators of inflammation :star: :point_right::skin-tone-5: kêu :speaking_head_in_silhouette: more leukocytes :point_right::skin-tone-5: amplifying :bomb: damage :skull_and_crossbones:
- - - - :octagonal_sign: hemolytic anemia
        
        :octagonal_sign::bug: faciliating phagocytosis :man::skin-tone-5::dagger_knife: with IgG :point_right::skin-tone-6: macrophage :deciduous_tree: come and posses receptor call Fc receptors :fork_and_knife: (:deciduous_tree::fork_and_knife:) :point_right::skin-tone-3: Fc receptor of Macrophage :fork_and_knife: recognize the Fc of IgG :bug: ( :octagonal_sign::bug::fork_and_knife::deciduous_tree:) :point_right::skin-tone-4: help Macropage engulf the entire cell ( :deciduous_tree:):sunglasses::clap::skin-tone-4:
      - thrombocytopenic purpura :sparkles::star::bug:
      - 2 bé RBC và Platelet gắn thêm auto antibody :bug: :point_right::skin-tone-6: :octagonal_sign::bug:, :star::bug: :point_right::skin-tone-5: trực tiếp có PƯ đặc biệt chống lại bản thân nó :hocho::man::skin-tone-4:
    - - Drug metabolites :hatching_chick::twisted_rightwards_arrows::chicken:
        
        Antibody :left_speech_bubble: adsorbed :bikini: on the suface of antigen :left_speech_bubble::admission_tickets:
- - - - complement protein C1 attaches :tanabata_tree: to antibody of the cell :point_right::skin-tone-6: Triggered :unlock: complement enzymatic reaction
        
        Complement proteins like C3,C4,C5 are cleaved :woman-lifting-weights::skin-tone-5: :point_right::skin-tone-6: The split C3a:pregnant_woman::skin-tone-2: ,C4a :pregnant_woman::skin-tone-3:,C5a :pregnant_woman::skin-tone-6: called anaphylatoxins :radioactive_sign: :point_right::skin-tone-6: Stimulate :sushi: mast cell :shaved_ice: release :shower:
        
        Histamin :white_flower:
        
        Inflamatory mediators :ferris_wheel:
        
        :arrow_double_up: increase vascular permeability :burrito::sweat_drops: :sweet_potato:
        
        help :open_hands::skin-tone-4: in extravastion :outbox_tray: of Neutrophils :point_right: Complement clevaved products C3a :pregnant_woman::skin-tone-2::heavy_plus_sign:C5a :pregnant_woman::skin-tone-6: are yếu tố hóa ứng động Chemotactic factors :point_right::skin-tone-5: attract :dancer::skin-tone-2::bikini: Neutrophils :dolphin:
        
        :point_right: Neutrophils are Activated :old_key::turkey: with their Fc receptor dính với Fc portion of the antibody :bug: :point_right::skin-tone-5: activated neutrophils release :shower: somthing :question::kissing_closed_eyes: :point_right::skin-tone-6: cell death :skull_and_crossbones:
    - - MAC attaches :tumbler_glass: to the cell membrane :point_right::skin-tone-5: creates channels on the cell surface :heavy_plus_sign: osmotic imbalance :saxophone: :point_right::skin-tone-5: Tb phân giải :eight_pointed_black_star: cell lysis
- - - - Perforins :chipmunk: create Pores :white_circle: in the cell
      - Granzymes :peach: enter :point_right::skin-tone-6:
- - - - Th1 ( chiếm tỷ lệ nhiều hơn) :arrow_right: bé Langerhands tiết ra IL-12 để giúp CD4+ T cell tiết ra nhiều Th1 :point_right::skin-tone-3: langerhans cell gắn với bà Th1 cell rồi bả đẻ ra Cytokine IFN gama :arrow_right: Cytokine IFN gama activated macrophage :arrow_right: với chức năng
        
        có antigen mạnh hơn 💪🏻
        
        tăng biểu hiện của MHC II 🪔📡
        
        Improved phagocytosing
        
        bà activated macrophage produce 🛠⚒ Pro-inflammatory cytokines là IL-1 & TNF alpha :point_right::skin-tone-6: causes monocyte leak out of 🧗🏻‍♀️ the nearby blood vessels :point_right::skin-tone-4: bà mono cyte chuyển thành macrophage :point_right::skin-tone-6: macrophage trở thành dạng activated 💨🎯 do IFN gamma phóng ra :point_right::skin-tone-5: bà macrophage tiếp tục phóng ra IL-12 để kiu thêm nhìu ông Th1 tới để phụ sx thêm ÌNF-gamma
        
        tích lũy accumulating Macrophages :arrow_right: tạo sự nhiễm trùng :bug: :arrow_right: release :
        
        Free radicals 🔆
        
        Lytic enzymes
        
        :arrow_right: loại bỏ 🔫 get rid of Foreign antigens/ Microbes :point_right::skin-tone-5: causing tissue damage :skull_and_crossbones:
        
        Nhưng 🙅🏻‍♀️🙅🏻‍♂️ bé Foregin antigens không chịu đi mà quyết tâm ở lại để Inflamation . Ví dụ bệnh: u hạt mãn tính chronic granulomatous infections do các bé này:
        
        tuberculosis 🥱
        
        sarcoidosis 👻
        
        Vì antigen vẫn còn ở lại trong cơ thể :point_right::skin-tone-4: cause tạo ra vòng lặp :cyclone: :
        
        TH1 cells activating Macrophages bằng IFN-γ
        
        Macrophage activating TH1 cells bằng IL-12
        :point_right::skin-tone-4: macrophage biến đổi Epitheloid cell :point_right::skin-tone-4: cause các epitheloid cells liền kề nhau dính lại :point_right::skin-tone-3: tế bào đa nhân khổng lồ Multinucleate giant cells like :
        
        Langhans giant cells
        
        Foreign body giant cells
        :point_right::skin-tone-4: 🤗🤗 hai bé này được bao quanh bới
        
        Lymphocyte ( TH1 cells)
        
        fibrosis
      - Th17 :arrow_right: lâu lâu bé Langerhands lại tiết ra IL1 & IL6 zòi :heavy_plus_sign: TGF-Beta :point_right: bắt thằng CD4 T cell tiết ra bé Th17 nhé :!!:
- - - - foods :stuffed_flatbread::poultry_leg:
      - Pollen :hibiscus:
      - Bee stings :bee:
      - :peanuts: peanuts
    - - Abdominal cramping
      - vomiting :open_mouth:
      - Difficulty breathing :tired_face:
      - tiêu chảy :japanese_ogre: diarrhea
    - - phù nề edema :balloon:
      - nổi mày đay Urticaria