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Rheum Disorders - Coggle Diagram

- - - - "NonRIM"
        
        Nonerosive arthritis
        
        Raynaud's phenomenon
        
        ILD
        
        Mechanic's Hands
        
        Dx: aminoacyl-tRNA synthetase... most commonly anti Jo1 antibodies
- - - - look at dsDNA
    - - antidsDNA
      - anti smith
      - antiphospholipid ab
    - - acute
      - subacute (antiro/SSA ab)
      - chronic (usually ANA negative if isolated DLE)
  - - - Moderate to severe: best for mucocutaneous and joint manifestations
- - - - more predictive for erosive disease
  - - - side effect: peripheral neuropathy
    - - Not potent-- but can be used in early disease
    - - Supposedly comparable to TNF except for radiographic progression
  - - - avoid in resp disease
- - - - less internal fibrosis -- most often PAH and CREST
      - ANA, anticentromere, antiTh
    - - GAVE more common. ILD more common too.
      - ANA, antiscl70 (higher risk of ILD)
        
        Rx: mycophenolate / rituximab / nintedanib
      - anti RNA polymerase III (scleroderma renal crisis)
        
        rx: captopril
        
        steroids increase risk for renal crisis
        
        Renal crisis = HTN emergency, headache, microangiopathic hemolytic anemia, schistocytes, thrombocytopenia, proteinuria
      - antiU3RNP
    - - organ only