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ANS drugs - Coggle Diagram

- - - - Prevents its storage into vesicle; VAT
    - - Bethanechol
        
        (M); poor lipid solubility
      - Carbachol
        
        Like Bethanechol but (B)
      - Pilocarpine
        
        Lipid soluble
    - - Edrophonium
        
        Short duration
      - Neostigmine
        
        Carbamate; poor lipid solubility
      - Pyridostigmine
        
        Like neostigmine but longer duration
      - Physostigmine
        
        Carbamate; better lipid solubility
      - Echothiophate/ Parathion/ Sarin
        
        Organophosphate; in order of increasing lipid solubility; poisonous
      - Rivastigmine
        
        Alzheimer's; like physostigmine
        
        Donepezil and Galantamine are two more Alzheimer drugs
  - - - Inhibit transport into nerve terminal
    - - Prevent release of Ach
    - - AchE regenerators
    - - M1-selective
        
        Pirenzipine
        
        Peptic ulcers
      - Slightly M3 selective
        
        Darinefacin/ Tolterodine
        
        Tx for stress incontinence
      - Nonselective
        
        Atropine
        
        Poisoning effects
        
        Scopolamine
        
        Motion sickness
        
        Benztropine
        
        Parkinsons
        
        Tropicamide/Cyclopentolate
        
        Eye usage
        
        Ipratropium/ Tiotropium
        
        Bronchodilation in asthma and COPD
        
        Oxybutynin
        
        Urgency in mild cystitis
    - - Ganglion blockers
        
        Hexamethonium
        
        Mecamylamine
      - Antinicotinic
        
        Tubocurarine
- - - - .
        
        Amphetamine
        
        Promote release; Anorexiant/ ADHD/ Narcolepsy
        
        Tyramine
        
        Hypertensive crisis
        
        Reserpine
        
        VMAT inhibition; prevent storage. depletes
        
        Cocaine/TCA
        
        Prevent reuptake back
        
        MAO inhibitors
        
        Prevent breakdown
        
        Ephedrine
        
        postural hypotension; enuresis; narcolepsy
    - - Norepinephrine
      - Epinephrine
    - - Alpha 1 selective
        
        Phenylephrine
        
        Nasal decongestant and ophthalmologic use
      - Alpha 2 selective
        
        Clonidine & Methyldopa & Brominidine
        
        Mild Hypertension & Glaucoma
    - - Nonselective
        
        Isoproterenol
      - Beta 1 selective
        
        Dobutamine
        
        CHF
      - Beta 2 selective
        
        Albuterol & Terbutaline
        
        Reverse bronchospasm/ suppress premature labor
        
        Salmeterol
        
        Longer action same principle/ used as prophylaxis or coadministration
  - - - Inhibit Tyrosine hydroxylase
    - - Prevents release
    - - Nonselective
        
        Irreversible
        
        Phenoxybenzamine
        
        Phreochromocytoma, mastocytosis, carcinoid syndrome, raynaud phenomenon
        
        Reversible
        
        Phentolamine
        
        Antidote to alpha agonist overdose, hypertension/ phreochromocytoma
      - Alpha 1 selective
        
        Prazosin
        
        Hypertension, BPH
        
        Terazosin, Doxazosin
        
        Longer duration
        
        Tamsulosin
        
        BPH DOC
      - Alpha 2 selective
        
        Yohimbine
        
        Outdated for ED
        
        Mirtazapine
        
        Atypical antidepressant; weight gain
    - - Nonselective
        
        Propranolol
        
        Angina; arrhythmia; hypertension; thyrotoxicosis; performance anxiety; migraine
        
        Timolol
        
        Glaucoma
        
        Pindolol
        
        Partial agonist
        
        Nadolol
        
        Longer duration like propranolol but less lipid solubility
      - Beta 1 selective
        
        Atenolol
        
        Not lipid soluble
        
        Esmolol
        
        acute SVT; IV for thyroid storm or hypertensive emergencies
        
        Metoprolol
        
        inverse agonist (like butaxolol)
        
        Nebivolol
        
        NO dependent vasodilating action
      - Beta 2 selective
        
        Butoxamine
      - Alpha + Beta blockers
        
        Labetalol/Carvedilol
        
        Hypertension and Hypertensive emergencies (IV)