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Systemic Lupus Erythematosus - Coggle Diagram
Systemic Lupus Erythematosus
Altered physiology
Genetic/familial
Hormonal & environmental
Common in women
exacerbations and quiescence
MHC and HLA systems appear to be involved in the development of autoimmune activity.
Clinical Manifestations
Fatigue
Pericardial effusion (swelling around the heart)
Skin rashes
Pleural effusion (swelling around the lungs)
Joint pain and swelling
Multi-system alterations in function
Kidney
Musculoskeletal
Skin
May develop
pulmonary disease
cardiac disease
neurological disease
Treatment
Varies among individuals
Early treatment: to minimize morbidity and mortality
Pharmacologic management
Corticosteroids
Disease modifying anti-rheumatoid drugs (DMARD)
non steroidal anti-inflammatory drugs (NSAIDs)
SLE - type III hypersensitivity reaction
Autoimmune disease and features responses from both innate and humoral immune systems
Chronic, systemic disease that can potentially damage a wide range of cell types and locations
the clinical manifestations contribute to the diagnosis and also can provide valuable information about the activity of the disease and the effectiveness of treatment strategies
Diagnosis
4 must be present to diagnose as SLE
Pleuritis
Proteinuria
Arthritis
Seizures/psychosis
Ulcers
Anemia, Leukopenia, or thrombocytopenia
Rash
Lab values including anti-DNA antibody, anti-Sm or false positive test for syphilis
Abnormal antinuclear antibody (ANA)