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Uremic Encephalopathy - Coggle Diagram
Uremic Encephalopathy
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prognosis
permanent structural changes and irreversible damage to the brain. Some encephalopathies can be fatal.
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Etiology
is a cerebral dysfunction caused by the accumulation of toxins as a result of acute or chronic renal failure. The clinical presentation is broad, and the clinical course is always progressive when untreated.
Risk Factor
may occur in a patient with acute kidney injury or chronic kidney failure of any etiology. One contributing factor to uremic encephalopathy may involve imbalances of neurotransmitter amino acids within the brain.
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Correcting the metabolic disturbance, which usually requires dialysis (hemodialysis or peritoneal dialysis) or renal transplantation. Symptoms improve as renal function improves. Seizures may be treated with anticonvulsants.
Treatment / Management
Studies have shown that the measured blood osmolality change is reduced by 60% with mannitol (10 mmol/kg fall in plasma osmolality was decreased to 4.3 mmol/kg with intravenous mannitol before HD). The symptoms of DDS were mild in the mannitol group and occurred in 10% of patients compared to 67% in the non-mannitol group despite similar ultrafiltration rates.
an organic brain disorder. It develops in patients with acute or chronic renal failure, usually when the estimated glomerular filtration rate (eGFR) falls and remains below 15 mL/min.