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Activity of acetyltransferase toxins involved in Salmonella persister…
Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection
Salmonella
Typhoidal
- Only infect Human to Human.
- Causing typhoidal fever and paratyphoid fever.
Non-Typhoidal
- Infect animal to human, human to animal.
- Causing gastroenteritis and food poisoning.
- Primarily in sub-Saharan Africa and kills 3-4 folds more than typhoid.
- Universally resistant to first, second line antibiotics.
- 78% of reinfection may due to growth resuscitation by persister formation.
Persister formation
- In TA system, activation of Toxin could interfere major cellular function, such as RNA translation, DNA replication, causing growth inhibition and become dormant state.
- In case of TacT toxin, through Acetylation of aminoacyl tRNA cause persister formation.
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