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Parasympathetic Drugs By ณัฐณิชา ประสมบุญ, Alzheimer’s disease, 1371EF7B…

- - - - Muscarine
      - Pilocarpine
        
        Glaucoma
        
        Dry mouth with Sjogren’s syndrome
      - Nicotine
        
        หยุดกะทันหัน -> hypertension
        
        For smoking cessation
    - - Nicotinic – pentameric ion channe
      - Muscarinic-G protein-coupled receptors
        (GPCR)
        
        Excitatory , M1 ,M3 ,M5
        
        Inhibitory,M2,M4
    - - ปัสสาวะราด
      - Astrid GI เยอะ
      - มองไกลเบลอ
    - - Carbamic acid ester
        
        Carbachol
        
        ตรวจม่านตา
        
        glaucoma
        
        Bethanechol
        
        Congenital megacolon
        
        Postoperative ileus
        
        most resistant
        
        ปัสสาวะยากม,diabetes
      - Acetic acid ester; poorly absorbed
        
        Methacholine
        
        resistant to hydrolysis
        
        diagnosis of bronchial airway hyperreactivity
        
        Acetylcholine
  - - - short-acting
        
        Edrophonium ไม่เข้า CFS
        
        Edrophonium
        
        Myastenia gravis;test
      - Intermidiate-Intermidiate-acting
        
        Pyridostigmine
        
        Myastenia gravis
        
        Physostigmine
        
        Neostigmine
        
        Paralytic ileus, urinary retention
        
        Myastenia gravis
    - - Organophosphates ; long-acting
        
        Echothiophate
      - War gases
      - Insecticides
    - - CNS ; convulsion ถ้าเข้าCFSได้
      - Neuromuscular action
        
        Muscle fasciculation
        
        Depolarization block
        
        Muscle paralysis
      - Precautions
        
        Coronary disease, Arrhythmia
        
        Asthma
        
        Obstruction of GI, Peptic diseases
        
        Obstruction of urinary tract
- - - - Atropine
        
        CVS; excessive vagal stimulation
        
        Combine with anesthesia;
        Inhibit secretion in RS tract
        
        Anticholinesterase poisoning
      - Scopolamine
        
        Motion sickness: แผ่นแปะ
      - Hyoscyamine
        
        Spastic conditions of GI
    - - Ipratropium
        
        Asthma, COPD: Inhibit M3
      - Dicyclomine
      - Tropicamide
      - Pirenzepine
        
        Peptic ulcer: Inhibit M1