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Penurunan Kesadaran Etc Uremic Encephalopathy - Coggle Diagram
Penurunan Kesadaran Etc Uremic Encephalopathy
Patofisiologi penurunan kesadaran (UE)
an imbalance of excitatory and inhibitory neurotransmitters in the brain
hormonaldisturbances
accumulation of metabolites,
altered intermediate metabolism
an increase in brain inflammation
an increase in vascular permeability
brain edema
an imbalance between excitatory and inhibitory neurotransmitters
the accumulation of false neurotransmitters such as methylguanidine and "middle molecules”
Definisi, Etiologi, Faktor Resiko Uremic Encephalopathy
Definisi
Uremic encephalopathy is an organic brain disorder. It develops in patients with acute or chronic renal failure, usually when the estimated glomerular filtration rate (eGFR) falls and remains below 15 mL/min
an acute condition of global cerebral dysfunction in the absence of primary structural brain disease
Etiologi
Accumulation of metabolites and, perhaps, imbalance in excitatory and inhibitory neurotransmitters are possible etiologies.
PTH and abnormal calcium control have also been identified as possible important contributing factors.
The exact cause of UE is unknown.
Faktor resiko
Hipertensi
electrolyte imbalance
drug toxicity
infection
Pathogenesis Encephalopathy
One contributing factor to uremic encephalopathy may involve imbalances of neurotransmitter amino acids within the brain
Management Emergency
Primary Survey
Airway
Clear
Breathing
Takypnea
Circulation
Disability
Secondary Survey
Early symptoms
Anorexia
Nausea
Restlessness
Drowsiness
Diminished ability to concentrate
Slowed cognitive functions
More severe signs and symptoms
Vomiting
Emotional volatility
Decreased cognitive function
Disorientation
Confusion
Bizarre behavior
Stupor, coma
Penunjuang, Tatalaksana
Penunjang
Darah lengkap
Elektrolit
KGD
Fungsi ginjal
Fungsi Hati
Tatalaksana
Dialysis
Transplantasi ginjal
OAE
Phenytoin
DD Uremic Encephalopathy
Dialysis encephalopathy/dementia
Alumunium accumulation
Hypertensive encephalopathy
Cerebral vasogenic edema
Wernicke-Korsakoff's encephalopathy
Thiamine deficiency
Drug toxicity
drugs metabolised or excreted by kidney immunosuppressive drugs
Komplikasi & Prognosis encephalopathy
Komplikasi
Seizure
Coma
Death
Prognosis
Dengan inisiasi RRT akan membaik
perubahan EEG membutuhkan beberapa bulan untuk pulih
beberapa kognitif di otak tidak dapat berubah