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4.2: Washed Out, 20 year old female, Paternal history of cardiovascular…

- - - - Loop diuretics
        
        Inhibits Na+/2Cl-/K+ triple cotransporter in the thick ascending limb
        
        Decreased K+ reabsorption
        
        Reduced K+ refeeder activity
        
        Reduced positive luminal charge
        
        Reduced Na+, K+, Mg+, Ca2+ reabsorption via paracellular shift
        
        7 more items...
        
        Decreased Na+ reabsorption
        
        Hyponatraemia
        
        Nausea
        
        High urinary Na+ relative to hyponatraemic state
        
        Decreased Cl- reabsorption
        
        Hypochloraemia
        
        Passes through efferent arteriole to vasa recta
        
        Competes with urea to be secreted into proximal convoluted tubule via OAT1 and OAT2
        
        Hyperuraemia
    - - Loss of fluid and electrolytes
  - - - Exclude anaemia (borderline)