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sickle cell anaemia - Coggle Diagram
sickle cell anaemia
investigation findings
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hypoxia-induced fatty changes in the heart, lover, and renal tubules
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elongated, spindled, or boat-shaped irreversibly sickled red cells
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treatment
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lifestyle
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Take folic acid supplements daily,
medications
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Hydroxyurea (Droxia, Hydrea, Siklos)
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definition
prototypic hemoglobinopathy, caused by a mutation in beta-globin that creates sickle hemoglobin (HbS)
pathogenesis
the sickling red cells initially is reversible on reoxygenation > membrane distortion leads to an influx of calcium> causes the loss of potasium and water> also damages the membrane skeleton> with time, cumulative damage creates irreversibly sickled cells that rapidly undergo hemolysis