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alpha-thalassemia - Coggle Diagram
alpha-thalassemia
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types
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hemoglobin H disease/HbH: 3 genes are missing, only 1 working gene
alpha thalassemia silent carrier: 1 gene is missing/damaged, the other 3 are normal
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investigation
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free-erythrocyte protoporphyrin, FEP and ferritin: to rule out iron-deficiency anemia
complete blood count, cbc: size, number, and maturity of different blood cells in a set volume of blood
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pathology
decreased alpha-globin production > fewer alpha-globin chains are produced> resulting in excess of beta chains in adults and excess gamma chains in newborns > forms unstable tetramers called hemoglobin h/hbh of 4 beta chains