Please enable JavaScript.
Coggle requires JavaScript to display documents.
Chap1 Downstream processing - Coggle Diagram
Chap1 Downstream processing
Biological constraints that influence bioreactor design
1) cell size
2) temperature & pH optima
3) Physical strength of the cell governed by cell wall structure
4) requirement for surface attachment exhibited by some mammalian cell
5) requirement for oxygen
6) cell growth rate
Process optimization
oxygen demand
off gas analysis
nature of mixing (impeller)
back pressure
rate of nature (agitation)
viscosity
pH
substrate feeding profile
temperature
broth analysis
process automation
sterility
time courses of fermentation mode
fed batch
continuous
batch