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What age group is the malaria vaccine most effective on? - Coggle Diagram
What age group is the malaria vaccine most effective on?
Host factors
Age
baby
toddler
child
teenager
adult
Genetics
Sex
male
female
Behavioural factors
Sleep
Smoking
Alcohol consumption
exercise
Nutritional factors
body mass index
micronutrients
In a trial in 450 children aged 5–17 months, the vaccine, called R21, was up to 77% effective at preventing malaria over the course of one year — which, if confirmed, would clear a 75% effectiveness target set by the World Health Organization.
A critical factor that makes the elderly more susceptible to infectious diseases is what immunologists call “immunosenescence”: the decline in the immune system’s functionality as people age. This is also associated with an increase in the incidence of inflammatory diseases, because an elderly body tends to be in a state of chronic low-grade inflammation.
Babies produce their own antibodies every time they are exposed to a virus or germ, but it takes time for this immunity to fully develop. The passive immunity passed on from the mother at birth also doesn't last long and will start to decrease in the first few weeks and months after birth.
Children aged under 5 years are the most vulnerable group affected by malaria; in 2019, they accounted for 67% (274 000) of all malaria deaths worldwide.
Hospital admissions with malaria parasites are more concentrated in younger children than is clinical malaria in all settings, and these severe cases become more concentrated in younger ages with increasing transmission intensity and less seasonality.
Vaccine
Administration factors
time of vaccination
schedule
site
route
other drugs
Vaccine factors
dose
product
adjuvant
vaccine type
storage conditions
Currently, the RTS,S malaria vaccine is expected to be stored at a temperature of 2–8°C