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Hypothalamo-Pituitary axis - Coggle Diagram
Hypothalamo-Pituitary axis
GHRH
GH
:warning:
Growth Hormone
留Na+
脂肪、肌肉細胞 insulin sensitivity↓→血糖↑
脂肪細胞 lipolysis
肝臟分泌
IGF-1
(somatomedin C)
#
#
insulin-like activity
antilipolytic activity
protein synthesis
epiphysial growth
肌肉細胞 protein synthesis
epiphysial growth : 長骨骨骺生長板chondrocyte分化
Dopamine
(PIH)
Prolactin(PRL)
泌乳素
孕期乳腺發育、產後
合成乳汁
immune function (cytokine receptor)
reproductive function : 抑制LH&FSH
CRH
POMC
(ProOpioMelanoCortin)
β-lipotropin (β-LPH)
β-endorphin 腦內啡
ACTH
(AdrenoCorticoTropic Hormone)
Adrenal action
cortisol
#
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Skin pigmentation
appetite regulation
immune modulation
下視丘
supraoptic nucleus(SON)
paraventricular nucleus(PVN)
oxytocin(OT) 催產素
分娩時子宮收縮→產出嬰兒
乳頭周圍肌肉收縮→
分泌乳汁
arginine
vasopressin
(AVP)/
ADH
(anti-diuretic hormone)
腎臟：V2 receptor→Gs→AC→cAMP→PKA
凝血：合成factor VIII & von Willebrand
集尿管AQP2再吸收水
血管舒張
血管平滑肌：V1a receptor→Gq→PLC→IP3→Ca2+
肝醣合成.
血管收縮
凝血：血小板聚集
GnRH
FSH
女 granulosa cell
inhibin
#
androgen→estrogen
#
#
男 Sertoli cell
MIS
inhibin
#
LH
女 theca cell
androgen
男 Leydig cell
testosterone
#
#
Somatostatin(SST)
#
體抑素
insulin↓
TRH
#
TSH