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AUTOIMMUNE DISEASE, Target single organ or gland, target or direct to any…
AUTOIMMUNE DISEASE
Etiological agents:
Viruses
Immunological disorder
Environmental
Pharmacological agents
Genetic
Systemic type
Systemic lupus erythematosus (SLE) in dogs
Pathogenesis
Apoptosis
Immune complexes deposition in various tissue (blood vessel& basement membrane)
composed of autoantibodies & antigens
activate complement system
release of cytokines
inflammation
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Lesion
Dermatologic lesion
alopecic, crusted, and scarred at nose, head, and ears
Histopathology
hyperkeratosis, Hydropic degeneration occurs in the basal cells of the epidermis edema of the dermis with fibrinoid deposits around collagen & Extravasation of erythrocytes
Syndrome:
autoimmune hemolytic anemia, thrombocytopenia, symmetrical polyarthritis, and immune complex (membranous) glomerulitis
Organ-specific type
Diabetes mellitus type 1
Pathogenesis
Etiological agents
form autoantigens
circulate in blood stream & lymphatics
Activation of T helper cell
release of cytokines
insulitis (inflammation of B cells)
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Target single organ or gland
target or direct to any different organs, tissue/cells