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What should be done to have success in the application of the malaria…
What should be done to have success in the application of the malaria vaccine?
Environment
Temperature
New vaccine currently needs to be stored in temperatures between 2 and 8 °C. Cold chain breach can occur when vaccine is stored outside these ranges which decreases the effectiveness of the vaccine permanently.
Moisture
Humidity
Season
Winter can make immune responses less effective
Summer can make immune responses more effective
Location
Different locations have different environmental conditions (temperature, humitidy,etc) which impact the effectiveness of the vaccine
Individual characteristics and Behavior
Alcohol Consumptions
Smoking
Exercise
Sleep
Body Mass
Malnutrition/underweight could decrease antibody responses
Obesity could decrease antibody responses
Being at a normal BMI range will likely be the best for vaccine efficacy
Age
Genetics
Stress
Approval
Ethics of usage
Consent?
Cost of treatment
How affordable is the vaccine
WIll it be cheap enough to eventually reach herd immmunity?
Safety
Contamination
Education needed due to absence of adequate knowledge?
Type of Education?
Article
Presentation
Video
Lifecycle of malaria parasite
Number of hosts
Specific host density
Location?
Administration of vaccine
Site
Time of vaccination
Usually the immune system is at its peak ability at night and is lowest during the day
Schedule
Are time intervals administered between doses?
Dosage Size
Higher concentration likely ellict stronger immune responses
Number of doses
Number of doses impact the immune response due to it alerting memory cells to remember the vaccine. Thus it slowly adapts the immune system against the pathogen
What defines success
Effective immune response?
Indicators of effective immune response
Contraction of Malaria parasite
Number of antibodies produced
Achieving herd immunity
Side effects?
redness
swelling