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IMMUNOLOGY-TB - Coggle Diagram
IMMUNOLOGY-TB
In the alveoli
Alveolar macrophage encounter the Mtb> recognize & alerted>activate>expand membrane>engulf the Mtb>phagocytoses(Receptors:TLR1/2)
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Lysosome>>migrate>match with phagosome>phagolysosome-pH drops>degrade the Mtb>activation of superoxide** >digestion> Pick up some proteins from Mtb(MHC-1 & MHC-2???)
Inflammatory chemokines released(TNF, IL-1Beta, IL-6 , 12 , 18)
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Mtb can inhibit acidification ,hydrolase activating, &superoxide burst(succeed to escape-fights back) by blocking the fusion of lysosome & phagolysosome)
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Antibodies
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Lung immunity when vaccinated:Th1,IL-10,IgA antibodies
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TRANSMISSION>>Diseased people>coughing/talking >Inhale Droplets>Mtb > host>lungs>alveoli(immune cells-macrophages
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