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Infiltrated amyloid imparts pressure on blood vessels to cause narrowing…

- - - - LIVER
        
        :star: swollen edges and rounded
        :star: doughy consistency and pits pressure
        :star: has cyanotic-yellow color and very friable
      - Kidney
        
        :star: swollen and has bulging surface when cut surface
        :star: has mottled red and yellow appearance
        :star: pale, waxy transluecency
    - - LIVER
        
        HE stain, there are deposition within sinusoids of a pink amorphous material (amyloid) and hepatocytes are atrophic
        
        HE stain, there is perivascular deposition of an eosinophilic material.
        
        Congo red stain, there is deposition of an amorphous orange stain material within the portal area and thickened arterial walls
        
        Congo red: arrow=Extensive amyloid deposition with obliteration of sinusoids was observed
        
        Histopathological diagnosis
        :star: Hepatic Amyloidosis
      - Kidney
        
        HE stain: (arrow)=diffusely glomerular tufts are segmentally everyplace expanded by variable amounts of amorphous, finely fibrillar to waxy, lightly eosinophilic material (amyloid)
        
        Congo red stain: Amyloid is stained orange color
        
        Congo red stain: Glomerular amyloid shows apple-green birefringence when transilluminated with polarized light.
        
        Histopathological Diagnosis
        :star: Renal amyloidosis
- - - - Most common form of amyloidosis in animals and is deposited in kidney, liver, spleen and lymph nodes