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Snake Venom - Coggle Diagram

- - - - Destabilization of sarcolemma
        
        Disruption of membrane permeability
        
        MYONECROSIS
  - - - Increase vascular permeability and vasodilation
        
        Extravasation of plasma fluid
        
        EDEMA
  - - - Necrosis of vascular endothelial cells
        
        Leakage of RBC outside of blood vessels
        
        SYSTEMIC HAEMORRHAGE
  - - - Increased vascular permeability
        
        Inflammatory cells infiltration
        
        Inflammation
        
        LOCAL TISSUE DAMAGE
  - - - Release of arachidonic acid
        
        Precursor for prostaglandins and leukotrienes
        
        Pro-inflammatory mediators
  - - - Tissue injuries
        
        Activate Hageman factor (FXII), a plasmatic factor
        
        Activate release of bradykinin
        
        Release of vasoactive peptides
        
        Fever and pain
- - - - Induce fibrinolysis
        
        Lack of clotting factor
        
        Haemorrhage
    - - Thrombin-like molecules
        
        Thrombus formation
  - - - Release of arachidonic acid
        
        Precursor for prostaglandins
        
        Release of Thromboxane A2
        
        Promote platelet aggregation
        
        Predispose to thrombus formation
        
        Release of Prostacyclin PGI2
        
        Inhibit platelet aggregation
        
        Predispose to haemorrhage