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PHYSIOLOGY pt.5 - Coggle Diagram

- - - - • pacemaker channel inhibition ( - chronotropism)
        • low cAMP ( - inotropism), AV delay ( - dromotropism)
      - Ach+Muscurinic+Gk(coupled toAch act. K+ channels
      - Muscarinic receptor-mediated effects
    - - Changes in Pressure
      - Carotid Sinus baro>>respond to ↓ & ↑ in pressure , Aortic Arch Baro>↑in pressure(all blood pass here)>>MAP detected
      - NervesIX(Carotid) & X(Aortic)
    - - Alpha 1
        
        Alpha+NA+Gq+PLC=PIP2>>IP3+DAG
        
        AP>>See more
        
        Skeletal vasodilation
      - Beta 1(heart) & B2(blood.v)
        
        NA+Beta+Gs+AC=ATP>>CaP
        
        Stimulation >SERCA(see more on notes)
        
        Cardiac inotropic/chonotropism/dromotropism
  - - - Happens when>↑Ca2+ & Cl- detected in DCT
      - Macula densa>adenosine>↑resistance
      - ↑ areteriolar resistance=↓ GFR
    - - ↑ transluminal pressure>>stretch act.>>Ca2+ pressure sensors>open>Ca2+>>constriction
      - ↓ Pressure>relax muscle>more BF
      - Auto smooth muscle>stretched by ↑ BP(↑renal BF)>> ↓BF