Physical Dependence
After 20 days of high doses
Withdrawal Symptoms
Yawning, rhinorrhea, diaphoresis, about 10 hours after last dose
Irritability, tremor, gooseflesh (cold turkey)
Sever symptoms - weakness, N/V, cramping, kicking (up to 7-10 days)
Avoid by tapering dosages over 3 days for therapeutic users; 7-10 days for abuse situations