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PHARMACOLOGY - Coggle Diagram
PHARMACOLOGY
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Mtb adapted to live intracellularly>>Mtb in phagosome>>acidic THUS , any drug should not only be able to Mycobacteria , but should penetrate the cells and phagosome where the pH is very Low
1ST LINE PROFILE
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Tox>>Peripheral Neuropathy(VitB6) ,Hepatitis
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P
Tox>>Gout,Hepatitis,Hypersensitivity
PK>Penetrates tissues well,activated @ low pH
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Tox>>Hepatitis, Hypersensitivity
PK>>Variable Bioavailability, Induce metabolism>increase interaction of drugs
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MoI>Activation of nuclear pregnane X receptor>ligand=rifampicin>transcription(CYT450 enzymes activated)>>conjugation>>efflux transporters>reduce molecules in blood
E
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PK>>Poor CNS penetration , renal elimination
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