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ADAPTIVE IMMUNITY - Coggle Diagram
ADAPTIVE IMMUNITY
Occur after the onset of infection, in which infectious organisms are not eliminated by innate immune mechanisms. It generate antigen-specific lymphocytes (effector cells) & memory cells that prevent reinfection with the same organism.
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PROPERTIES
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MEMORY
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2nd activation of lymphocytes by same Ag produces more rapid & stronger response than the primary response
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LYMPHOID ORGANS
SECONDARY/PERIPHERAL
Lymph Nodes, Spleen, MALT
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TYPES
CMI - T CELLS
Direct lysis of the infected cells - intracellular microbes (viruses) replicating within infected cells - CTL
Produce Cytokines - activate infected cells (Macrophage) to kill the pathogens/phagocytosed microbes - Th cells
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EFFECTOR CELLS
B CELLS & T LYMPHOCYTES
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T cells develop in BM & mature in thymus. Then migrate to peripheral lymphoid organs - activated upon encounter with foreign Ag
Mature naive lymphocytes continuously recirculating in these tissue - pathogen Ag are carried by DC from the site of infection
Naive lymphocytes that don't encounter with Ag leave through efferent lymphatic organs & return to blood - continue to recirculate through lymphoid tissue - until they recognise Ag or die
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