Please enable JavaScript.
Coggle requires JavaScript to display documents.
receptor, nociceptor 痛覺接受器 # # # - Coggle Diagram
receptor
感覺接受器
photoreceptor
視錐、視桿
thermoreceptor
冷熱
chemoreceptor
下視丘osmoreceptor
主/頸動脈體 血氧接受器&CO2
mechanoreceptor
主/頸動脈竇 血壓接受器baroreceptor
腎臟入球小動脈JG cell
muscle spindle
Golgi tendon organ
荷爾蒙接受器、下游傳訊
signal mechanism& hormone action
receptor for water-soluble hormone
ligand-gated ion channel
(ionotropic receptor)
Nicotinic cholinergic receptor
ACh
enzyme
receptor tyrosine kinase (RTK)
insulin receptor
tyrosine kinase-associated receptor + JAK
(cytokine receptor superfamily)
growth hormone
prolactin
leptin
receptor serine/threonine kinase
receptor granylyl cyclase
G-protein-coupled receptor (GPCR)
(metabotropic receptor)
(ligand多為neurotransmitter)
second messenger
(ATP→Adenyl cyclase)
cAMP
Protein Kinase A (PKA)
PhosphoDiEsterase
(phosphorylase)
(PIP2→Phospholipase C, PLC)
DAG
Protein Kinase C (PKC)
IP3
(Ca2+ channel)
Ca2+
(膜磷脂→PhosphoLipase A2, PLA2)
arachidonic acid & eicosanoids
(autocrine、paracrine
→血管、發炎、凝血相關)
cyclooxygenase pathway
prostaglandin (PGI2)
發炎、血管舒張
Thromboxane A2 (TxA2)
凝血、血管收縮
lipoxygenase pathway
leukotrienes 白三烯素
過敏、發炎
receptor
𝝱2 adrenegic receptor
epinephrine
Muscarinic cholinergic receptor
ACh
G protein
Gs
活化enzyme、ion channel
αs subunit會促進cAMP生成（increase cAMP）
Gi
抑制enzyme、ion channel
αi subunit參與調控離子通道開關（Ion channels）、抑制cAMP生成（inhibition cAMP）、活化脂質水解酶（Phospholipases）促進脂質水解、活化小腸磷酸二酯酵素（Phosphodiesterases）促進cGMP水解
G12
α12 subunit會活化Rho GEFs，Rho GEFs可活化Rho-family GTPases，Rho-family GTPases為調節細胞骨架（actin）組裝的因子
Gq
αq subunit會活化脂質水解酶C（Phospholipase C）
receptor for lipid-soluble hormone
carrier/binding protein
純運輸、不可引起生理反應
nuclear receptor superfamily
steroid hormone receptor
性激素、cortisol
thyroid hormone receptor
Thyroxine
receptor for vitamin D, retinoic acid
vit A、vit D
orphan receptor
未知ligand＆功能
nociceptor
痛覺接受器
#
#
#