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AGONIST AND ANTAGONIST - Coggle Diagram
AGONIST AND ANTAGONIST
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HISTAMINE
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- HOW CAN SOME FOOD LIKE BUDU, CENCALUK AND BELACAN INDUCE ALLERGY IN HUMANS?
HISTAMINES IS COMMONLY FOUND IN FERMENTED FOOD AS IT IS PRODUCED BY FERMENTATION PROCESS THAT INVOLVED BACTERIA.FERMENTED FOOD RICH IN HISTIDINE .
BACTERIA THAT INVOLVED IN FERMENTATION PROCESSCONTAIN HISTIDINE DECARBOXYLASE THAT CHANGE HISTIDINE TO HISTAMINE.
AS A RESULT HISTAMINE WILL INCREASE THE BLOOD FLOW AND CAUSE ALLERGY SYMPTOM LIKE ITCHING AND SNEEZING.
4.WHAT IS AN ANTAGONIST FOR A RECEPTOR? WHAT WOULD AN ANTAGONIST DO? DRAW A DIAGRAM TO EXPLAIN FOR NICOTINE AND DAPOMINE RECEPTORS.
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DIAGRAM
NICOTINE&DOPAMINE 
ANTAGONIST INHIBITS AGONIST BINDING TO THE RECEPTOR . ANTIHISTAMINE IS AN ANTAGONIST FOR HISTAMIN RECEPTORS.
HISTAMINE WILL BE RELEASED WHEN OUR BODY DETECTS SOMETHING HARMFUL. ANTIHISTAMINE WILL BLOCK HISTAMINE TO BIND TO THE H1 RECEPTOR. OUR BODY'S REACTIVITY TO ALLERGEN REDUCED.SOME HISTAMINE HAVE AN ANTIMUSCARINIC EFFECT THAT INHIBIT A DIFFERENT SORT OF RECEPTOR THAT FOUND ON THE SURFACE OF CERTAIN CELLS.
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- LIST DOWN THE TYPES OF ANTIHISTAMINES AVAILABLE . EXPLAIN THE MECHANISM OF ACTION AND THEIR SIDE EFFECTS.
MECHANISM OF ACTION
ASSUME THE ROLE OF INVERSE AGONISTS. H1 ANTIHISTAMINES BIND TO H1 RECEPTOR ON TARGET TISSUE AND KEEP IT IN AN INACTIVE STATE. iNHIBITS HISTAMINE ACTION, RESULTING ALLERGY SYMPTOMS LIKE ITCHING AND INFLAMMATION.
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STEROIDS
- LISTDOWN THE EXAMPLES OF STEROID DRUGS.HOW DOES THIS DRUG WORK?
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- WHAT IS ANTAGONIST FOR STEROID RECEPTOR?WHAT WOULD ANTAGONIST DO?DRAW A DIAGRAM TO EXPLAIN.
ANTAGONISTS BIND TO STEROID RECEPTORS BUT DO NOT ACTIVATE THEM RESULTING IN REDUCE OR NON-EXISTENT RESPONSE
DIAGRAM
ANTAGONIST FOR STEROID RECEPTOR IS SUCH A DRUG THAT BLOCKS THE STEROID FROM THE STEROID RECEPTOR LIKE MIFEPRISTONE
- WHAT ARE STEROIDS RECEPTOR?WHERE ARE THIS RECEPTORS LOCATED IN THE CELL? HOW DO THEY WORK?DRAW A DIAGRAM.
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HOW DO THEY WORK?
STEROID HORMONE EASILY DIFFUSE ACROSS THE PLASMA MEMBRANE OF A CELL THEN BIND TO THE STEROID RECEPTOR. HORMONE RECEPTOR COMPLEX PRODUCED. RECEPTOR ACTIVATION OCCURRED AND BIND TO A SPECIFIC REGION OF DNA CAUSED THE TRANSCRIPTION PROCESS AND PRODUCE mRNA FOR PROTEIN SYNTHESIS
STEROID RECEPTORS ARE INTRACELLULAR RECEPTOR WHICH IS BIND TO THE NON-WATER SOLUBLE HORMONE. GENE EXPRESSION WILL CHANGE DUE TO THE ACTIVATING SIGNAL TRANSDUCTION. EXAMPLE ESTROGEN RECEPTORS AND PROGESTERON RECEPTORS.
DIAGRAM
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