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ANTIGEN, Naturally occurring, Immune occurring, Alloantibody, DNA…
ANTIGEN
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IMMUNOGEN
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Certain compounds that are incapable of inducing an immune response, yet they are capable of binding with component of the immune system
ANTIGENICITY
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Ability to recognise & combine specifically with the final products of immune response (Ab / surface on T-cells)
IMMUNOGENICITY
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REQUIREMENTS
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Dosage, route & timing of Ag administration
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EPITOPES
CHARACTERISTICS
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Ab bind epitopes toughly 5 AA or sugar in size, while TCR bind epitopes between 8-17 AA in size
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Nature of Ag
B cells - Protein, polysaccharides, lipid
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Epitopes recognised
B cells - Accessible, sequential or non-sequential: conformational / discontinuous
T cells - Internal linear peptides produces by Ag processing (proteolytic degradation_ - continuous/linear
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PAMPS
Bacterial & yeast cell wall products, bacterial & viral DNA / viral RNA
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Alloantibody
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Produced after exposure to foreign Ag (RBC, WBC, Platelet Ag after blood transfusion/transplantation
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After birth (3-6 months) - Maternal IgG declines & protection from maternal IgG is lost during this time
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