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Learning Issues - Coggle Diagram
Learning Issues
Status epilepticus
Definition
tatus epilepticus (SE) is a common, life-threatening neurologic disorder that is essentially an acute, prolonged epileptic crisis
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Edukasi
Epilepsi dapat terjadi kapan saja. Risiko kecelakaan terutama pada tipe dengan gangguan kesadaran, sering terjadi. Pasien membutuhkan pengawasan khusus pada saat berdekatan dengan lingkungan air seperti di sekitar kolam atau saat mandi. Epilepsi tidak memungkinkan pasien untuk berkendara sendiri, berenang atau bekerja pada bidang yang berdekatan dengan penggunaan api atau alat berat.
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Prognosis
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setelah tahun pertama, rekurensi rendah
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patofisiologi kejang
Seizures are paroxysmal manifestations of the electrical properties of the cerebral cortex. A seizure results when a sudden imbalance occurs between the excitatory and inhibitory forces within the network of cortical neurons in favor of a sudden-onset net excitation.
The release of GABA from the interneuron terminal inhibits the postsynaptic neuron by means of 2 mechanisms: (1) direct induction of an inhibitory postsynaptic potential (IPSP), which a GABA-A chloride current typically mediates, and (2) indirect inhibition of the release of excitatory neurotransmitter in the presynaptic afferent projection, typically with a GABA-B potassium current. Alterations or mutations in the different chloride or potassium channel subunits or in the molecules that regulate their function may affect the seizure threshold or the propensity for recurrent seizures.
GABA neurons are activated by means of feedforward and feedback projections from excitatory neurons. These 2 types of inhibition in a neuronal network are defined on the basis of the time of activation of the GABAergic neuron relative to that of the principal neuronal output of the network, as seen with the hippocampal pyramidal CA1 cell.
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