psoriasis

definisi

diagnosa banding

diagnosa psoriasis vulgaris

klasifikasi

tatalaksana

patofisiologi psoriasis

patofisiologi kulit tebal bersisik

predileksi

golongan penyakit kulit dengan effloresensi : eritema, papula, skuama

Penyebab utama psoriasis adalah disregulasi respons imun adaptif yang dimediasi sel

regenerasi kulit pada penyakit ini 3-4 hari, normalnya -+28 hari

kulit mental akibat proliferasi dan mitosis abnormal dari keratinosit

Psoriasis Plak atau Vulgaris

Psoriaris Pustular

Psoriasis Eritrodermik

Psoriasis Kuku

Psoriasis Gutata

Psoriasis Inverse

dysregulation of the cell-mediated, adaptive immune response

This dysregu- lation is likely triggered by hyperactivity of the innate immunological surveillance system to environmental antigens.

This overproduc- tion of Th1-related cytokines along with IL-12, -17, and -23 causes hyperproliferation of epidermal keratinocytes

lead to the formation of the psoriatic plaques

Physical Examination

Anamnesis

Laboratory Findings

Histopatologi

Auspitz sign

keluhan utama

epidermal hyperplasia, parakeratosis, thinning of the granular layer

“Munro abscesses” (intraepithelial collec- tions of neutrophils)

The primary lesion is a scaly, red- to salmon- pink-colored papule

Koebner phenomenon

It is usually cov- ered by a white or silvery scale that, when removed, may show pinpoint bleeding

plaques may occur in an area after trauma, pressure, or injury

RPT

RPO

RPK

kulit menebal, besisik, merah dan gatal

apakah pernah mengalami gejala ini sebelumnya (berhubungan dgn autoimun)

penggunaan obatobat bisa memicu (beta blocker, lithium)

diturunkan secara genetik

systemic

topical

The differential diagnosis of psoriasis includes other
papulosquamous diseases

Seborrheic dermatitis

Tinea corporis

Pityriasis rosea

Plaque-type psoriasis is classically an extensor disease often involving the knees, elbows

gluteal cleft, lumbosacral region, and the umbilicus. Psoriasis may involve the scalp

area yang sering terpapar trauma

psoriasis arthritis

fotokemotrapi

UVA

UVB

indikasi lesi > 10% permukaan tubuh

indikasi lesi < 3% permukaan tubuh

metotreksat, siklosporin, retinoid, sulfasalazin

analog vitamin D, tar (LCD 3-10%), kortikosteroid, asam salisilat

prognosis

kronik dan residif

Faktor pencetus lainnya; infeksi,obat tertentu, stres, perubahan iklim, trauma