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Enzymology Pt1 - Coggle Diagram

- - - - Reversible inhibitors interact with an enzyme via non-covalent association
    - - Irreversible inhibitors interact with the enzyme via covalent association
      - Competitive
        
        The inhibitor (I) binds only to the enzyme (E) and not to the enzyme-substrate complex (ES)
        
        The inhibitor competes with substrate (S) for binding to the active site
      - Noncompetitive
        
        The inhibitor (I) binds to either the enzyme (E) and/or to the enzyme-substrate (ES)
      - Uncompetitive
        
        The inhibitor (I) and substrate (S) bing together to the active site to form an EIS complex
- - - - v = -Delta[A]/Delta[t] = k[A]
  - - - v=k[A][B]
        
        reaction order is the sum of all the individual reaction orders - first order for [A], first order for [B] BUT second order overall
        
        units - v=M/s; [A] = M; [B] = M then k=M^-1s^-1
- - - - Substrates bind to active site
        
        E+S<-> ES <-> EP <-> E+P
  - - - The energy derived from enzyme-substrate binding is derived from multiple weak, no covalent bonds and interactions
- - - - Substrate bind to active site which are composed of a group of particular amino acids tat assist the catalytic process