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HAEMOSTASIS PART 2 - Coggle Diagram
HAEMOSTASIS PART 2
5.FIBRINOLYSIS
Plasminogen: tPA go to fibrin>bind lysine sites
tPA cleaves plasminogen>plasmin>dissolves fibrin clot>blood flow restoration
Thrombin>stimulate release of tPA
Plasmin released by:
urokinase, contact activation & kallikrein
Enzymatic breakdown of the fibrin in blood clots.
Fibrinolysis inhibited by: PAI & PAI 2
Secondary Haemostasis
(Coagulation Cascade)
Participant:
3.Coagulation Factors
Process
1.Initiation of thrombin generation
Intrinsic Pathway
XIa activates IX>IXa
Intrinsic tenase formed(IXa:VIIIa)>activates X
Thrombin activate FV,platelets & FVIII & XI
Extrinsic Pathway
Generation of small amount
Xa+ thrombin
>>start fibrin formation
TF inhibitor blocks Xa & ext. pathway
Extrinsic tenase formed(TF:VIIa) on Tissue bearing Cells
2.Amplification
Amplifies intrinsic pathway & final common pathway
Result:larger thrombin production
3.Propagation
of thrombin generation
4.Stabilisation(fibrin formation)
weak platelet plug>fibrin clot
XII(activated by THrombin>cross links n >stabilize fibrin polymers
Generation of fibrin>stabilizes & transforms platelet
Require Calcium
Innate Immunity & Coagulation
Infection=thrombosis risk
Upregulation of TF & pro-inflammatory cytokines
Complement system
INHIBITION OF COAGULATION
Participant:
4.Anticoagulants
inhibitors
Physiological
Intact endothelium>separate platelets from Thr. substances
Prostacyclin & NO(endothelial derived)>vasodilators
Specific
Protein C>inhibit F5 ,8
Protein S & thrombomodulin
ARIII>Inhibit Factor 10,9,12 & fibrin
TFPI