Please enable JavaScript.
Coggle requires JavaScript to display documents.
HAEMEOSTASIS(Coagulation) - Coggle Diagram
HAEMEOSTASIS(Coagulation)
Haemeostasis>balanced response by
Procoagulant & Anticoagulant
3 INTERGRATED PROCESSES
Anticoagulation>stop clot formation
Fibrinolysis>break down clot
Coagulation>formation of Clot
Primary Homeostasis
Participants
1.Blood vessel wall/endothelium
2.Platelet Plug Formation
Process
1.endothelium(Vascular Spasm)
Roles: inflammation, BP control & homeostasis
Injury>vasoconstriction>
procoagulant
(e.g Protein S)
& anticoagulants secreted
(e.g Tissue Factor)
>balance shifted>
Clotting
>Acute/Chronic Vascular Thrombosis
Risk factors for Chronic Thrombosis:
Atherosclerosis(hypercholesterolemia, smoking), diabetes, obesity
2.Platelet Plug Formation
rapid interaction btwn. blood platelets subendothelium &
Von Willebrand Factor
(vWF)
Events
Ø Platelet adhesion
Injury>
ProC
subendothelial matrix exposed>
vWF
bridges
GPIb
+subendothelial>
GPIIb/IIa
binding sites exposed>further binding of platelets by
vWF & Fibrinogen
Ø Platelet activation
Activators: Collagen,adp,thrombi,adrenalin,TXA2
Activators+receptors>
Cascade intracellular phosphorylation
>intracellular platelet Ca2+ release>
platelet cytoskeleton changes
(shape, platelet granule contents release&
TXA2 synthesis
via
arachidonic acid
pathway
> increases activation)
Ø Platelet aggregation
Activated platelets with GPIIb/IIIB + Fibrinogen>
Crosslink
>aggregates
Platelet activation + shape changes>increase
surface area suitability
>enable coagulation cascade reactions to occur
5 COMPONENTS
blood
vessel wall
Platelet Plug Formation
fibrinolysis
Anticoagulants
coagulation
factors
Virchow's Triad
Venous stasis
Hypercoagulative state
Altered endothelial