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Back from Extinction - Coggle Diagram

- - - - DNA half life ~500 years so after 7 million years all DNA destroyed
      - dinosaurs went extinct <60mya
  - - - Excellent captive breeding
      - one of shortest gestation periods (13.5 days) and one of most altricial young of any mammal
      - ability to culture the conceptus throughout the entire period of utero development
      - derivation of dunnart spermatogonial cells in vitro
        
        potential cell line to do gene editing
        
        simplified approach to creating an animal
        
        developing robut methods to derive these cells in marsupial species
        
        excellent resource for conservation efforts
        
        genome edit spermatogonial stem cells, colonise testis, breed animals standard way
- - - - 95% thylacine DNA
    - - 40X (120 billion bases)
- - - - Marsupial bears or hyenas, sabre toothed cats, marsupial lions fossils found across 'gondwana'
    - - closest relative = numbat
      - part of the dasyurid family
- - - - naturally found in hedgehogs
      - using IPSCs in dunnarts as a mid step (has worked in dunnart cells so far!)
      - can engineer resistance to toads in quolls, quolls don't go extinct and can help control spread of toads