Please enable JavaScript.
Coggle requires JavaScript to display documents.
OTHER CARDIAC DISEASES:CARDIOMYOPATHIES, image, image, image - Coggle…
OTHER CARDIAC DISEASES:CARDIOMYOPATHIES
DEFINE
Cardiac disease due to
Primary abnormality
of myocardium
FEATURES
Cardiomegaly
Endocardial thickening
No risk factors caused by abnormality of valves/coronary arteries, past/present HPT
Fibrosis of Ventricular myocardium(depends on severity)
Abnormal contractility or filling
Mural thrombi
4.
ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY
Results
>>Right sided Heart failure, Sudden Death, cardiac arrhythmias
Characteristics/Features
Thinned Right ventricle
Loss of cardiac myocytes
replacement by adipocytes
Interstitial fibrosis
genetic abnormality(autosomal dominant)
2.HYPERTROPHIC
Clinical consequences
=angina pectoris, late cardiac failure/sudden death
MORPHOLOGY
Macroscope
: Asymmetrical hypertrophy of ventricular septum(
S-shaped
)>>blocks LV outflow tract
Microscope
: Myocytes: hyperchromatic nuclei ,short ,broad ,disarrayed
Description
Autosomal dominant
condition(
Chromosome 14 abnormality
)
Mutations in troponin and myosin genes >>impaired diastolic filling>>LVH
Hypercontractile of LV>>
Double apex impulse
3.
RESTRICTIVE
AETIOLOGY
: idiopathic , infiltrative lesions in myocardium(amyloidosis & sarcodosis
MORPHOLOGY
Macroscope
Normal sized ventricles
++enlarged atria, Subendocardial fibrosis
ventricular thrombi
Microscope
: inflammatory infiltrates(eosinophils)
Defect in LV compliance
>>resistance in filling, loss of elasticity(rigidity due to thickened endocardium)
1.
DILATED CARDIOMYPATHY
Associations
: Alcohol ,thiamine deficiency, postpartum period, viral myocarditis, chemotherapy, haemochromatosis,
Supraphysiologic stress
,
GENETIC FACTORS
: Abnormality of genes & proteins(e.g titin), mitochondrial defects .
MORPHOLOGY
Microscope
:myocyte hypertrophy, underperfusion>>myocytolysis>>interstitial & replacement fibrosis, cardiac dilatation>>proliferation of endocardium S.M cells
Macroscope
: increased weight, globular heart shape, flabby myocardium, thickening of free edge of mitral leaflets, mural thrombi in ventricles>>endocardial scars
Systolic Dysfunction>>impaired contractility>>>
Dilatation of all 4 chambers
