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OBESITY - Coggle Diagram
OBESITY
CUSHINGS DISEASE
too much cortisol
manifests as
moon face
buffalo hump
truncal obesity
muscle wasting in legs
stretch marks (striae)
stretching of skin
rupture of subnormal tissues
purple
diabetes
symptoms develop in a short period of time
redistribution of body fat?
Harvey Cushing discovered
causes
pituitary gland
adenoma
microadenoma
benign tumour of epithelial origin
adrenal gland
tumor
condition in which excess fat has accumulated in the body
BMI
body weight in kg /height in m2
not necessarily a good indicator
range
normal range = 20-25
Grade I = 25-30
Grade II = 30-40
Grade III = >40
morbidly obese
Causes
increase in food consumption & decrease in energy expenditure
Genetic disorder (v. rare)
pathological conditions
APPETITE CONTROL
leptin
protein
encoded by
ob gene
mice
rats
humans
homozygous mutations in ob gene
no leptin production
patient never feels full after meal
develops obesity and diabetes
leptin in adipocytes are absorbed into the blood
goes to hypothalamus (feeding centre)
goes to leptin receptor
leads to a decrease in neuropeptide Y
decreases in neuropeptide Y (NPY - 36 amino acid peptide
increase in energy expenditure
decrease in food intake
167 amino acid protein