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ALZHEIMER'S DISEASE AND DEMENTIA - Coggle Diagram
ALZHEIMER'S DISEASE AND DEMENTIA
progressive disease that destroys memory and other important mental functions causing brain to shrink and brain cells to die
clinical manifestation
forget names of family members
difficulty in multitasking
get lost in familiar places
repeat statements and questions over and over
difficulty in remembering recent events or conversation
depression, apathy and mood swings(Fadi Massoud et al. Can J pschiatry.2011 oct)
memory loss
pathophysiology
beta-amyloid deposition and neurofibrillary tangles lead to loss of synapses
neuron's resulting in gross atrophy starting at mesial temporal lobe.
causes
combination of genetics, lifestyle
abnormal buildup of beta-amyloid and tau proteins around brain cells
and environmental factors affecting brain over time
risk factors
family history and genetics
head trauma
down syndrome
mild cognitive impairment
age as you grow older
diagnostic studies
brain-imaging tests
lab tests for B12 vitamin
neuropsychological tests
mental status testing
pharmacological management
donepezil
rivastigmine
galantamine
memantine